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Highly Enantioselective Transfer Hydrogenation of Polar Double Bonds by Macrocyclic Iron(II) / (NH)2P2 Catalysts

Macrocyclic iron(II) / (NH)2 P2 complexes were tested in the large-scale (100 mmol) asymmetric transfer hydrogenation of aryl alkyl ketones and imines in 2-propanol. Ten substrates, including challenging ones such as tert-butyl phenyl ketone and industrially relevant molecules such as 3,5-bis(trifluoromethyl)acetophenone, were reduced in high yield (89.0 – 99.7%), excellent enantioselectivity (95.8 – 99.4% ee), and with low catalyst loadings (S / C up to 10’000 / 1). Read more 

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